| First Author | Maison C | Year | 2012 |
| Journal | Nat Struct Mol Biol | Volume | 19 |
| Issue | 4 | Pages | 458-60 |
| PubMed ID | 22388734 | Mgi Jnum | J:245338 |
| Mgi Id | MGI:5918100 | Doi | 10.1038/nsmb.2244 |
| Citation | Maison C, et al. (2012) The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Nat Struct Mol Biol 19(4):458-60 |
| abstractText | SUMOylation promotes targeting of HP1alpha to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1alpha accumulation at this location. SENP7 interacts directly with HP1alpha, localizes at HP1-enriched pericentric domains and can deconjugate SUMOylated HP1alpha in vivo. Depletion of SENP7 delocalizes HP1alpha from pericentric heterochromatin without affecting H3K9me3 levels. We propose that following targeting of HP1alpha, a subsequent deSUMOylation event enables HP1alpha retention at these domains. |
