| First Author | Gao C | Year | 2020 |
| Journal | bioRxiv | PubMed ID | 32766577 |
| Mgi Jnum | J:296125 | Mgi Id | MGI:6467710 |
| Doi | 10.1101/2020.07.29.227462 | Citation | Gao C, et al. (2020) SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors. bioRxiv |
| abstractText | The spike (S) glycoprotein in the envelope of SARS-CoV-2 is densely glycosylated but the functions of its glycosylation are unknown. Here we demonstrate that S is recognized in a glycan-dependent manner by multiple innate immune receptors including the mannose receptor MR/CD206, DC-SIGN/CD209, L-SIGN/CD209L, and MGL/CLEC10A/CD301. Single-cell RNA sequencing analyses indicate that such receptors are highly expressed in innate immune cells in tissues susceptible to SARS-CoV-2 infection. Binding of the above receptors to S is characterized by affinities in the picomolar range and consistent with S glycosylation analysis demonstrating a variety of N- and O-glycans as receptor ligands. These results indicate multiple routes for SARS-CoV-2 to interact with human cells and suggest alternative strategies for therapeutic intervention. |
