| First Author | Wanzel M | Year | 2008 |
| Journal | Nat Cell Biol | Volume | 10 |
| Issue | 9 | Pages | 1051-61 |
| PubMed ID | 19160485 | Mgi Jnum | J:240385 |
| Mgi Id | MGI:5883209 | Doi | 10.1038/ncb1764 |
| Citation | Wanzel M, et al. (2008) A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol 10(9):1051-61 |
| abstractText | The Myc-associated zinc-finger protein, Miz1, is a negative regulator of cell proliferation and induces expression of the cell-cycle inhibitors p15(Ink4b) and p21(Cip1). Here we identify the ribosomal protein L23 as a negative regulator of Miz1-dependent transactivation. L23 exerts this function by retaining nucleophosmin, an essential co-activator of Miz1 required for Miz1-induced cell-cycle arrest, in the nucleolus. Mutant forms of nucleophosmin found in acute myeloid leukaemia fail to co-activate Miz1 and re-localize it to the cytosol. As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest. |
