| First Author | Irie M | Year | 1997 |
| Journal | Science | Volume | 277 |
| Issue | 5331 | Pages | 1511-5 |
| PubMed ID | 9278515 | Mgi Jnum | J:113666 |
| Mgi Id | MGI:3687405 | Doi | 10.1126/science.277.5331.1511 |
| Citation | Irie M, et al. (1997) Binding of neuroligins to PSD-95. Science 277(5331):1511-5 |
| abstractText | PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins. |
