| First Author | Xie J | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 20 | Pages | 3011-7 |
| PubMed ID | 18692052 | Mgi Jnum | J:201313 |
| Mgi Id | MGI:5512958 | Doi | 10.1016/j.febslet.2008.07.048 |
| Citation | Xie J, et al. (2008) SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF. FEBS Lett 582(20):3011-7 |
| abstractText | We identified intersectin1 (ITSN1) as a new binding partner of the SH2 domain containing inositol 5-phosphatase 2 (SHIP2). The interaction between SHIP2 and ITSN1 was confirmed in vivo. Src homology 3D, A, C, and E domains of ITSN1 were shown to be implicated in the interaction. In response to epidermal growth factor, SHIP2 expression could recruit the ITSN1 short form (ITSN1-S) to the cell membrane, while SHIP2 overexpression did not modulate the ITSN-mediated extracellular signal-regulated kinase1/2 and c-Jun NH2-terminal kinase activation. Our data provide a molecular link between SHIP2 and ITSN1 which are involved in receptor endocytosis regulation. |
