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Comment :

Type  MGI:General Description  tau tangles are seen as early as 2-3 months after doxycycline removal (at 6 weeks after birth to induce gene expression) in the entorhinal cortex and amygdala by 15 months after doxycycline removal, neurofibrillary tangles are seen in the neocortex neurofibrillary tangles persist in mice that are doxycycline treated for 4 months after 10 months of transgene expression