| Type | MGI:General | Description | mice infected with SARS-CoV-2 (strain hCoV-19/England/Liverpool_REMRQ0001/2020) alone show a 100-fold higher sgRNA (measuring active virus infection) at day 3 dpi SARS-CoV-2 than 7 dpi 6 days post SARS-CoV2 infection, viral antigen is detected in multifocal patches of individual to large groups of alveoli, randomly throughout the parenchyma, and in type I and type II pneumocytes and in endothelial cells in capillaries and small vessels in septa but not within bronchiolar epithelial cells 7 days post only SARS-CoV-2 infection, mice show multifocal areas with distinct type II pneumocyte activation and syncytial cell formation with mild mononuclear infiltration and mild to moderate lymphocyte-dominated vasculitis and perivascular infiltration, a few areas of mild desquamative pneumonia with intra-alveolar macrophages/type II pneumocytes, edema, and fibrin deposition |
