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Comment :

Type  MGI:General Description  abnormalities are seen in mutant embryos beginning at E7.5, when apoptotic cells are detectable in the embryo proper by E8.5, mutant embryos show growth arrest and considerable apoptotic cell death in the embryo proper by E9.5-E10, 50% of the mutant embryos are undergoing resorbtion, with the remainder showing severe abnormalites