| Type | MGI:General | Description | at 8-10 weeks of age, male homozygotes display a higher sensitivity to acute exercise-induced muscle injury than wild-type males, as indicated by histopathology and beta-glucuronidase activity studies in quadriceps femori samples the increase in beta-glucuronidase activity between exercised and unexercised mutant runners is 311% vs 190% between exercised and unexercised wild-type runners although muscle damage varies between individuals, mutant runners generally have more numerous skeletal muscle fibers undergoing degeneration and more intensive inflammation than wild-type runners |
