| Type | MGI:General | Description | as early as 2 weeks, mutant lungs show a progressive (age-dependent) increase in the average space between opposing alveolar walls mutant alveoli are not homogeneously enlarged; however, the average alveolar size is significantly increased at all ages examined (2 weeks to aged) in aged homozygotes, the average alveolar size is increased by ~50% in aged homozygotes, lungs show a significant decline in hydroxy-proline content, consistent with alveolar enlargement; this decline is not statistically significant at 4-8 months |
