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Type  MGI:General Description  homozygous null embryos displayed a specific defect in vessel bifurcation at the chorioallantoic junction, leading to severe undervascularization in the placental labyrinth unlike the wild-type labyrinth, the mutant labyrinth was saturated with maternal blood sinuses and few fetal vessels were detected notably, trophoblast nuclei were evident in both wild-type and mutant labyrinth, and differentiation of the labyrinthine syncytiotrophoblasts appeared normal