| Type | MGI:General | Description | CLP-treated mutant mice show worsening of lung function, increased edema, and leukocyte accumulation mice exposed to acid aspiration show worsened oxygenation, massive lung edema, increased inflammatory cell infiltration and hyaline membrane formation compared to controls mice exhibit enhanced acute lung injury after acid aspiration, cecal ligation and perforation (CLP), or endotoxin challenge compared to controls pharmacological inhibition of angiotensin II type 1 receptor with Losartan attenuates the severity of acid-induced lung injury however, inhibition of angiotensin II type 2 receptor with PD123.319 has no effect on the acute lung injury |
