| Type | MGI:General | Description | in vitro, mutant dendritic cells are defective in costimulating T cell cytokine production when used as stimulators in a mixed lymphocyte reaction (MLR) with wild-type BALB/c (H-2d) CD4+ T cell responders, mutant 129/Sv (H-2b) dendritic cells stimulate significantly lower levels of IL-4 and IFN-gamma production (<30% and <5% of wild-type, respectively), while IL-2 is moderately reduced (<65% of wild-type) |
