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Comment :

Type  MGI:General Description  mice treated with tamoxifen at 4 weeks of age develop exostosis in the metacarpal-phalangeal and metatarsal-phalangeal joints and the distal radius/ulna with continuity from the metaphyseal bone adjacent to the growth plate mice first develop nodule formations in the dorsal hands and feet and in the wrist and ankle joints 2 weeks after tamoxifen treatment bony nodules in the hands of tamoxifen treated mice arise from the metaphyseal region of the metacarpal bone and cartilaginous matrix in the nodules originates form the groove of Ranvier cartilaginous nodules in the feet of tamoxifen treated mice form in the metaphysis of the distal metatarsal bones