| Type | MGI:General | Description | terminal profiles in the neuropil are enlarged and in contact with multiple Purkinje cell (PC) spines, often engulfing them, resulting in highly convoluted terminal contours; however density of asymmetrical synapses on PCs is significantly decreased relative to controls parallel fiber (PF) terminals are sparse, with many appearing coarse and intense on basis of Slc17a7 (VGluT1) immunolabeling; some PF-PC synapses show a 1:1 contact between PF terminals and PC spines but other exhibit large PF terminals forming multiple contacts climbing fiber (CF) terminals are irregular in shape and size; innervation stops midway along proximal dendrites; number of perisomatic CF terminals per unit area of somatic surface is markedly higher than in controls on basis of Slc17a6 (VGluT2) immunolabeling regressed innervation territory of climbing fibers on Purkinje cells down to basal dendrites and somata is observed in mutants resulting in multiple innervation |
