| First Author | Sugiyama H | Year | 2013 |
| Journal | Genes Cells | Volume | 18 |
| Issue | 6 | Pages | 519-28 |
| PubMed ID | 23611113 | Mgi Jnum | J:268010 |
| Mgi Id | MGI:6270911 | Doi | 10.1111/gtc.12056 |
| Citation | Sugiyama H, et al. (2013) Interaction of Necl-4/CADM4 with ErbB3 and integrin alpha6 beta4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly. Genes Cells 18(6):519-28 |
| abstractText | Nectin-like molecule 4 (Necl-4)/CADM4, a transmembrane cell-cell adhesion molecule with three Ig-like domains, was shown to serve as a tumor suppressor, but its mode of action has not been elucidated. In this study, we showed that Necl-4 interacted in cis with ErbB3 through their extracellular regions, recruited PTPN13 and inhibited the heregulin-induced activation of the ErbB2/ErbB3 signaling. In addition, we extended our previous finding that Necl-4 interacts in cis with integrin alpha6 beta4 through their extracellular regions and found that Necl-4 inhibited the phorbol ester-induced disassembly of hemidesmosomes. These results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly. |
