| First Author | Shimojo M | Year | 2003 |
| Journal | Mol Cell Biol | Volume | 23 |
| Issue | 24 | Pages | 9025-31 |
| PubMed ID | 14645515 | Mgi Jnum | J:172884 |
| Mgi Id | MGI:5009175 | Doi | 10.1128/MCB.23.24.9025-9031.2003 |
| Citation | Shimojo M, et al. (2003) REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Mol Cell Biol 23(24):9025-31 |
| abstractText | The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors. |
