| First Author | Schreiner D | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 22 | Pages | 5295-300 |
| PubMed ID | 16979624 | Mgi Jnum | J:201260 |
| Mgi Id | MGI:5512845 | Doi | 10.1016/j.febslet.2006.08.079 |
| Citation | Schreiner D, et al. (2006) The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. FEBS Lett 580(22):5295-300 |
| abstractText | The cadherin superfamily protein Fat1 is known to interact with the EVH1 domain of mammalian Ena/VASP. Here we demonstrate that: (i) the scaffolding proteins Homer-3 and Homer-1 also interact with the EVH1 binding site of hFat1 in vitro, and (ii) binding of Homer-3 and Mena to hFat1 is mutually competitive. Endogenous Fat1 binds to immobilised Homer-3 and endogenous Homer-3 binds to immobilised Fat1. Both, endogenous and over-expressed Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells. As Homer proteins and Fat1 have been both linked to psychic disorders, their interaction may be of patho-physiological importance. |
