| First Author | Zhang L | Year | 2020 |
| Journal | Cell Immunol | Volume | 358 |
| Pages | 104221 | PubMed ID | 33035772 |
| Mgi Jnum | J:303508 | Mgi Id | MGI:6514486 |
| Doi | 10.1016/j.cellimm.2020.104221 | Citation | Zhang L, et al. (2020) PHF14 is required for germinal center B cell development. Cell Immunol 358:104221 |
| abstractText | Germinal centers (GCs), which are the site of antibody diversification and affinity maturation, are vitally important for humoral immunity. GC B cell proliferation is essentially for these processes by providing enough templates for somatic hypermutation (SHM) and serving as a critical mechanism of positive selection. In the current study, we found a significant reduction of GC response in the spleens of GC B cell specific PHF14 knockout (PHF14(GCB KO)) mice compared with the wild-type control (PHF14(GCB WT)) when the mice were challenged with SRBCs or lymphocytic choriomeningitis virus. We also demonstrated that PHF14 did not affect the cell survival of GC B cells, but regulated the proliferation of GC B cells. In addition, PHF14 suppressed the expression of Cdkn1a (p21) though regulating the level of H3K4me3 to control the proliferation of GC B cells. Collectively, our data suggest that PHF14 plays an important role in the process of germinal center formation by regulating GC B cell proliferation in spleen. |
