| First Author | Ma W | Year | 2012 |
| Journal | Pflugers Arch | Volume | 463 |
| Issue | 4 | Pages | 585-92 |
| PubMed ID | 22311122 | Mgi Jnum | J:345438 |
| Mgi Id | MGI:7606439 | Doi | 10.1007/s00424-012-1077-z |
| Citation | Ma W, et al. (2012) Pannexin 1 forms an anion-selective channel. Pflugers Arch 463(4):585-92 |
| abstractText | Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-) approximately glutamate (-) approximately gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance. |
