| First Author | Liu L | Year | 2003 |
| Journal | Blood | Volume | 102 |
| Issue | 9 | Pages | 3206-9 |
| PubMed ID | 12855566 | Mgi Jnum | J:113929 |
| Mgi Id | MGI:3687881 | Doi | 10.1182/blood-2003-05-1419 |
| Citation | Liu L, et al. (2003) Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Blood 102(9):3206-9 |
| abstractText | In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified. |
