| First Author | Thompson EL | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 323 |
| Issue | 1 | Pages | 65-71 |
| PubMed ID | 15351702 | Mgi Jnum | J:250044 |
| Mgi Id | MGI:6102465 | Doi | 10.1016/j.bbrc.2004.08.058 |
| Citation | Thompson EL, et al. (2004) Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight. Biochem Biophys Res Commun 323(1):65-71 |
| abstractText | Hypothalamic neuromedin U (NMU) appears to have a role in the regulation of appetite and the hypothalamo-pituitary-adrenal (HPA) axis. Acute administration of NMU into the paraventricular nuclei (iPVN) increases plasma adrenocorticotrophic hormone and corticosterone, and inhibits food intake in fasted rats. No studies have as yet investigated the chronic effects of centrally administered NMU. We investigated the effect of twice-daily iPVN injections of 0.3 nmol NMU for 7 days on food intake, body weight, the HPA axis, and behavior in freely fed rats. Chronic iPVN NMU was not associated with a decrease in food intake or body weight. Chronic iPVN NMU produced a typical behavioral response on day 1 and day 4 of the study, and resulted in the elevation of plasma corticosterone present 18 h after the final injection. These results suggest NMU may have a role in the regulation of the HPA axis and behavior. |
