| First Author | Yoshida K | Year | 2002 |
| Journal | J Lipid Res | Volume | 43 |
| Issue | 11 | Pages | 1770-2 |
| PubMed ID | 12401877 | Mgi Jnum | J:113960 |
| Mgi Id | MGI:3687912 | Doi | 10.1194/jlr.c200010-jlr200 |
| Citation | Yoshida K, et al. (2002) Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res 43(11):1770-2 |
| abstractText | Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro. |
