| First Author | Chae YS | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 8 | Pages | 1128-34 |
| PubMed ID | 22575646 | Mgi Jnum | J:201295 |
| Mgi Id | MGI:5512940 | Doi | 10.1016/j.febslet.2012.03.021 |
| Citation | Chae YS, et al. (2012) Cell density-dependent acetylation of DeltaNp63alpha is associated with p53-dependent cell cycle arrest. FEBS Lett 586(8):1128-34 |
| abstractText | DeltaNp63alpha is a p63 isoform that is predominantly expressed in the epidermal stem cells and in cancer. To find the regulatory pathways of DeltaNp63alpha, we assessed whether DeltaNp63alpha is acetylated and determined the functional implications of acetylation. First, the hinge region of p63 was shown to be acetylated by PCAF, similarly to other p53 family members. Second, acetylation synergistically induced cytoplasmic localization of DeltaNp63alpha. Finally, acetyl-DeltaNp63alpha was induced during high-density culture, suggesting that acetylation of DeltaNp63alpha may reinforce cell cycle arrest upon cell contact. Altogether, these findings suggest that acetylation of DeltaNp63alpha contributes to the epidermal homeostasis. |
