| First Author | Yazicioglu MN | Year | 2013 |
| Journal | J Biol Chem | Volume | 288 |
| Issue | 36 | Pages | 25908-25914 |
| PubMed ID | 23873930 | Mgi Jnum | J:313845 |
| Mgi Id | MGI:6204603 | Doi | 10.1074/jbc.M113.484683 |
| Citation | Yazicioglu MN, et al. (2013) Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2. J Biol Chem 288(36):25908-14 |
| abstractText | The genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins were identified and characterized more than a decade ago, but their functions remain unknown. These novel membrane proteins have an extracellular gamma-carboxyglutamic acid (Gla) protein domain and cytosolic WW binding motifs. We screened WW domain arrays for cytosolic binding partners for PRRG4 and identified novel protein-protein interactions for the protein. We also uncovered a new WW binding motif in PRRG4 that is essential for these newly found protein-protein interactions. Several of the PRRG-interacting proteins we identified are essential for a variety of physiologic processes. Our findings indicate possible novel and previously unidentified functions for PRRG proteins. |
