| First Author | Traut W | Year | 2001 |
| Journal | Chromosoma | Volume | 110 |
| Issue | 4 | Pages | 247-52 |
| PubMed ID | 11534816 | Mgi Jnum | J:71113 |
| Mgi Id | MGI:2149194 | Doi | 10.1007/s004120100152 |
| Citation | Traut W, et al. (2001) Evolution of a 6-200 Mb long-range repeat cluster in the genus Mus. Chromosoma 110(4):247-52 |
| abstractText | By fluorescence in situ hybridization, we mapped the location of genes associated with the Sp100-rs cluster, a long-range repeat cluster in chromosome 1 of the house mouse, Mus musculus. The cluster comprises between 60 and 2000 repeats and extends over 6-200 Mb of the M. musculus genome, depending on the source of the cluster. The cluster evolved during the last two million years in the genus Mus in the lineage to which M. musculus belongs. The Asiatic mouse species M. caroli is not in this lineage and does not possess the cluster. M. caroli represents the ancestral genomic organization of the cluster source components Sp100, Csprs and Ifi75: they are located close to each other in the same chromosome band (1D). However, Sp100-rs, the principal gene of the cluster, is not present in the M. caroli genome. It is a chimeric M. musculus gene that arose by fusion of Csprs and the 5' part of Sp100. Sp100-rs and Ifi75 are homogeneously distributed throughout the cluster while Sp100 and Csprs in its original sequence context flank the cluster on opposite sides. Our results suggest a model for the origin and evolution of the long-range repeat cluster by duplication, gene fusion and amplification. |
