| First Author | Timmons PM | Year | 2002 |
| Journal | Development | Volume | 129 |
| Issue | 3 | Pages | 635-47 |
| PubMed ID | 11830565 | Mgi Jnum | J:74242 |
| Mgi Id | MGI:2157791 | Doi | 10.1242/dev.129.3.635 |
| Citation | Timmons PM, et al. (2002) The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis. Development 129(3):635-47 |
| abstractText | The seminiferous epithelial cycle and spermatogenic wave are conserved features of vertebrate spermatogenic organisation that reflect the need for the rigorous maintenance of sperm production. Although the cycle and the wave of the adult seminiferous epithelium have been well characterised, particularly in rodent species, their developmental origins are unknown. We show that the Sertoli cells of the pre-pubertal mouse, including those of the germ cell-deficient XXSxra mutant, exhibit coordinated, cyclical patterns of gene expression, presaging the situation in the adult testis, where Sertoli cell function is coupled to the spermatogenic cycle. In the case of the galectin 1 gene (Lgals1), localised differential expression in the Sertoli cells can be traced back to neonatal and embryonic stages, making this the earliest known molecular marker of functional heterogeneity in mammalian testis cords. In addition, the timing of germ cell apoptosis in normal pre-pubertal testes is linked to the temporal cycle of the Sertoli cells. These data show that the cycle and wave of the murine seminiferous epithelium originate at a much earlier stage in development than was previously known, and that their maintenance in the early postnatal cords depends exclusively on the somatic cell lineages. |
