| First Author | Simpson E | Year | 1987 |
| Journal | Nature | Volume | 326 |
| Issue | 6116 | Pages | 876-8 |
| PubMed ID | 3494951 | Mgi Jnum | J:8692 |
| Mgi Id | MGI:57157 | Doi | 10.1038/326876a0 |
| Citation | Simpson E, et al. (1987) Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome. Nature 326(6116):876-8 |
| abstractText | The mammalian Y chromosome encodes a testis-determining factor (termed TDF in the human), a master regulator of sex differentiation. Embryos with a Y chromosome develop testes and become males whereas embryos lacking a Y chromosome develop ovaries and become females. Expression of H-Y, a minor histocompatibility antigen, may also be controlled by a gene on the Y chromosome, and it has been proposed that this antigen is the testis-determining factor. We have tested the postulated identity of H-Y and TDF in the human. H-Y typing with T cells was carried out on a series of sex-reversed humans (XX males and XY females), each shown by DNA hybridization to carry part but not all of the Y chromosome. This deletion analysis maps the gene for H-Y to the long arm or centromeric region of the human Y chromosome, far from the TDF locus, which maps to the distal short arm. |
