| First Author | Waltenbaugh C | Year | 1985 |
| Journal | Eur J Immunol | Volume | 15 |
| Issue | 9 | Pages | 922-6 |
| PubMed ID | 3930262 | Mgi Jnum | J:8020 |
| Mgi Id | MGI:56489 | Doi | 10.1002/eji.1830150911 |
| Citation | Waltenbaugh C, et al. (1985) I-J expression is not associated with murine chromosome 4. Eur J Immunol 15(9):922-6 |
| abstractText | I-J originally mapped within the murine major histocompatibility complex (H-2) between the EB and Ea loci using intra-H-2 recombinants. Cloning of this segment of H-2 shows no DNA that can be ascribed to I-J. Various hypotheses have attempted to explain this dilemma. One hypothesis attributes a chromosome 4 locus with I-Jk expression. This hypothesis requires the AKR/J and A/WySn mouse strains to be I-Jk negative. In the present report we show that AKR/J spleen cells express I-Jk surface molecules and that both the AKR/J and A/WySn mouse strains produce functional I-Jk-bearing suppressor factors to poly(Glu50Tyr50). Our data imply that mapping of I-J-determining genes to chromosome 4 may be premature. |
