| First Author | Womack JE | Year | 1976 |
| Journal | Genetics | Volume | 82 |
| Issue | 4 | Pages | 665-75 |
| PubMed ID | 57899 | Mgi Jnum | J:5641 |
| Mgi Id | MGI:54118 | Doi | 10.1093/genetics/82.4.665 |
| Citation | Womack JE (1976) Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus. Genetics 82(4):665-75 |
| abstractText | Recombination between Esterase-4 and Esterase-2 in the rat was not observed in 278 backcross offspring. Es-4 is thus included within the esterase cluster in Linkage group V. A new map of this region was constructed and the relationship of the four esterase loci was found to be: Es-4-(9.6+/-1.6 cM)-Es-2, Es-4-(1.5+/-0.7cM)-Es-3. Homology of this region with a region of Linkage Group XVIII (Chromosome 8) of the mouse was proposed on the basis of tissue distribution, subcellular localization and response of enzymes to inhibiotrs. Specifically, rat Es-1 was suggested as the homolog of mouse Es-6. An autosomal segment comprising at least 15cM of the rat and mouse genomes appears to have remained relatively intact with respect to genetic content during rodent speciation. In addition, a new polymorphism for mouse esterase was described. The locus was designated Esterase-10 (Es-10) and proposed as the mouse homolog of human Esterase D. Linkage of Es-10 with nucleoside phosphorylase-1-(Np-1) on Chromosome 14 was established. |
