First Author | Skow LC | Year | 1987 |
Journal | Genomics | Volume | 1 |
Issue | 3 | Pages | 283-6 |
PubMed ID | 2895729 | Mgi Jnum | J:9121 |
Mgi Id | MGI:57584 | Doi | 10.1016/0888-7543(87)90057-7 |
Citation | Skow LC, et al. (1987) Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals. Genomics 1(3):283-6 |
abstractText | Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome. |