| First Author | Petitto JM | Year | 1990 |
| Journal | Brain Behav Immun | Volume | 4 |
| Issue | 1 | Pages | 39-49 |
| PubMed ID | 2334815 | Mgi Jnum | J:27050 |
| Mgi Id | MGI:74468 | Doi | 10.1016/0889-1591(90)90005-b |
| Citation | Petitto JM, et al. (1990) Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol. Brain Behav Immun 4(1):39-49 |
| abstractText | Natural killer cell activity was compared in the Long-Sleep and Short-Sleep mouse lines. These mice, initially selected for their sensitivities to a hypnotic dose of ethanol, are also differentially sensitive to other agents which act through the benzodiazepine/GABA receptor chloride ionophore complex. Natural killer cell activity was 40-59% lower in Short-Sleep when compared to Long-Sleep mice. Flow cytofluorometric analysis demonstrated that the number of Nk-1+ cells was also lower in the spleens of Short-Sleep than Long-Sleep mice. In addition, the incidence of 3-methylcholanthrene-induced tumors was significantly greater in Short-Sleep (85.7%) than in Long-Sleep (14.3%) mice. These results suggest that the Long-Sleep and Short-Sleep mouse lines may represent a unique model to assess the physiological role of the benzodiazepine/GABA receptor chloride ionophore complex in the neural modulation of immune function. |
