| First Author | Stephan D | Year | 1986 |
| Journal | J Exp Med | Volume | 163 |
| Issue | 5 | Pages | 1227-44 |
| PubMed ID | 3701254 | Mgi Jnum | J:8271 |
| Mgi Id | MGI:56740 | Doi | 10.1084/jem.163.5.1227 |
| Citation | Stephan D, et al. (1986) Organization and evolution of D region class I genes in the mouse major histocompatibility complex. J Exp Med 163(5):1227-44 |
| abstractText | Chromosome walking has been used to study the organization of the class I genes in the D and Qa regions of the MHC of the BALB/c mouse and in the D region of the AKR mouse. Five and eight class I genes are found in the D and Qa regions of the BALB/c mouse, respectively, while the AKR mouse contains only a single class I D region gene that has been identified by transfection as the Dk gene. Restriction map homologies and crosshybridization experiments suggest that the multiple class I genes in the D region of the BALB/c mouse have been generated by unequal crossing-over involving class I genes from the Qa region. The expanded D region of BALB/c and other H-2d haplotype mouse strains appears to be metastable, since evidence for gene contraction in the Dd region has been found in two mutant strains. Thus the D region and also the Qa region class I genes are in a dynamic state, evolving by gene expansion and contraction. |
