| First Author | Bartlett MS | Year | 1991 |
| Journal | J Protozool | Volume | 38 |
| Issue | 6 | Pages | 130S-131S |
| PubMed ID | 1818136 | Mgi Jnum | J:544 |
| Mgi Id | MGI:49081 | Citation | Bartlett MS, et al. (1991) Inoculated mouse model of Pneumocystis carinii pneumonia. J Protozool 38(6):130S-131S |
| abstractText | A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats. |
