| First Author | Mosselman S | Year | 1988 |
| Journal | FEBS Lett | Volume | 239 |
| Issue | 2 | Pages | 227-32 |
| PubMed ID | 3181427 | Mgi Jnum | J:17773 |
| Mgi Id | MGI:65801 | Doi | 10.1016/0014-5793(88)80922-0 |
| Citation | Mosselman S, et al. (1988) Islet amyloid polypeptide: identification and chromosomal localization of the human gene. FEBS Lett 239(2):227-32 |
| abstractText | Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12. |
