| First Author | Yague J | Year | 1988 |
| Journal | Nucleic Acids Res | Volume | 16 |
| Issue | 23 | Pages | 11355-64 |
| PubMed ID | 2849763 | Mgi Jnum | J:9520 |
| Mgi Id | MGI:57980 | Doi | 10.1093/nar/16.23.11355 |
| Citation | Yague J, et al. (1988) The structure of V alpha and J alpha segments in the mouse. Nucleic Acids Res 16(23):11355-64 |
| abstractText | Antigen receptors on most T-cells are heterodimeric glycoproteins, comprised of an alpha chain and a beta chain. These chains are encoded by discontiguous variable (V), diversity (D) and joining (J) gene segments that rearrange to produce a contiguous and functional alpha or beta chain gene. To investigate the size and diversity of the germline repertoire of alpha-chain gene segments, we have characterized and sequenced 20 alpha chain cDNAs. Among these cDNA clones, we have found 4 J alpha and 4 V alpha sequences that have not yet been described. The relationship of these new gene segments to those already characterized is discussed. |
