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Publication : From white spots to stem cells: the role of the Kit receptor in mammalian development.

First Author  Fleischman RA Year  1993
Journal  Trends Genet Volume  9
Issue  8 Pages  285-90
PubMed ID  7691001 Mgi Jnum  J:14202
Mgi Id  MGI:62376 Doi  10.1016/0168-9525(93)90015-a
Citation  Fleischman RA (1993) From white spots to stem cells: the role of the Kit receptor in mammalian development. Trends Genet 9(8):285-90
abstractText  The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
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