| First Author | Lopez M | Year | 1995 |
| Journal | Gene | Volume | 155 |
| Issue | 2 | Pages | 261-5 |
| PubMed ID | 7721102 | Mgi Jnum | J:24403 |
| Mgi Id | MGI:72169 | Doi | 10.1016/0378-1119(94)00842-g |
| Citation | Lopez M, et al. (1995) Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene. Gene 155(2):261-5 |
| abstractText | The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11. |
