First Author | Stapleton P | Year | 1993 |
Journal | Nat Genet | Volume | 3 |
Issue | 4 | Pages | 292-8 |
PubMed ID | 7981748 | Mgi Jnum | J:4336 |
Mgi Id | MGI:52831 | Doi | 10.1038/ng0493-292 |
Citation | Stapleton P, et al. (1993) Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet 3(4):292-8 |
abstractText | In the human paired box-containing (PAX) gene family, only two members, PAX-3 and PAX-6, which are associated with Waardenburg's syndrome and aniridia, respectively have been mapped to human chromosomes. We have now isolated cosmids for six additional human PAX genes (PAX-1,-2,-5,-7,-8,-9) and a polymerase chain reaction fragment for PAX-4. PAX-9 is a novel family member which is closely related in its paired domain to PAX-1. The chromosomal location of all cloned PAX genes was determined by analysis of somatic cell hybrids and (except PAX-4) by fluorescence in situ hybridization to metaphase chromosomes. PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci. |