| First Author | Kristensen NM | Year | 1996 |
| Journal | Int Immunol | Volume | 8 |
| Issue | 7 | Pages | 1091-8 |
| PubMed ID | 8757954 | Mgi Jnum | J:38179 |
| Mgi Id | MGI:85568 | Doi | 10.1093/intimm/8.7.1091 |
| Citation | Kristensen NM, et al. (1996) Induction of T cell responses to the invariant chain derived peptide CLIP in mice immunized with the group 1 allergen of house dust mite. Int Immunol 8(7):1091-8 |
| abstractText | In this study we demonstrate that immunization of H-2(b) mice with the allergen Der p 1 induces MHC class II restricted T cells that proliferate to residues 15-29 of Der p 1 (p15-29) and to the murine MHC class II-associated invariant chain derived peptide (CLIP). T cells from naive H-2(b) mice and those immunized with murine CLIP fail to respond to either CLIP or p15-29. T cell lines and clones reactive with p15-29 strongly proliferate in response to splenic antigen-presenting cells (APC) from normal H-2(b) mice but show reduced proliferation to APC from invariant chain deficient mice. Furthermore, T cells isolated from Der p 1 primed mice and expanded on H-2(b) spleen cells in the absence of the p15-29 epitope retained specificity for both p15-29 and CLIP, suggesting that naturally presented self components can act as mimetic peptides and may maintain T cell memory to foreign antigens. |
