| First Author | Park MS | Year | 1995 |
| Journal | J Biol Chem | Volume | 270 |
| Issue | 26 | Pages | 15467-70 |
| PubMed ID | 7797537 | Mgi Jnum | J:26786 |
| Mgi Id | MGI:74218 | Doi | 10.1074/jbc.270.26.15467 |
| Citation | Park MS (1995) Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells. J Biol Chem 270(26):15467-70 |
| abstractText | Processing of mutagenic DNA damages by the double strand breaks (DSB) in eukaryotes is most likely achieved by multiple pathways, including homologous recombination. Although RAD52 has been shown to be important for DSB repair in yeasts, its role in DSB repair in mammalian cells has not been demonstrated. This study reports for the first time that the overexpression of human RAD52 confers enhanced resistance to gamma-rays and induces homologous intrachromosomal recombination in cultured monkey cells. Recombination frequency synergistically increased by the combination of overexpression of RAD52 and ionizing radiation. These observations suggest that homologous recombination mediated by RAD52 is involved in double-stranded break repair in mammalian cells. |
