| First Author | Litaker W | Year | 1996 |
| Journal | Mamm Genome | Volume | 7 |
| Issue | 3 | Pages | 200-5 |
| PubMed ID | 8833240 | Mgi Jnum | J:32012 |
| Mgi Id | MGI:79514 | Doi | 10.1007/s003359900054 |
| Citation | Litaker W, et al. (1996) A physical map of the Q region of B1O.P. Mamm Genome 7(3):200-5 |
| abstractText | The murine class I MHC Q region is part of a large complex multigene family whose members have various peptide binding functions. The structure of the Q region is complex, varying extensively in the b, d, k, and q haplotypes so far examined. To better understand the structural heterogeneity, we examined the Q region of B10.P, a strain whose immunological characteristics are distinct from other haplotypes. A total of 89 cosmids were isolated from genomic DNA. The B10.P Q region was found to contain seven genes in a 190-kb cluster linked to D-p and two additional Q genes in a separate 55-kb cluster. The gene arrangement in this haplotype was unique and did not correspond to any other haplotype; this underscores the complexity of chromosomal structure in this region. In addition to the Q region clusters, Tla region was tentatively aligned in five clusters spanning approximately 300 kb. One 37-kb M region cosmid was also identified. |
