| First Author | Tojo H | Year | 1995 |
| Journal | Neurosci Lett | Volume | 192 |
| Issue | 3 | Pages | 169-72 |
| PubMed ID | 7566642 | Mgi Jnum | J:27377 |
| Mgi Id | MGI:74797 | Doi | 10.1016/0304-3940(95)11637-c |
| Citation | Tojo H, et al. (1995) Neurotrophin-3 is expressed in the posterior lobe of mouse cerebellum, but does not affect the cerebellar development. Neurosci Lett 192(3):169-72 |
| abstractText | We replaced the neurotrophin-3 (NT-3) gene with Escherichia coli-derived lacZ via homologous recombination in embryonic stem (ES) cells and generated the mutant mice. Here we show the in vivo expression of NT-3 in the cerebellum during the postnatal period. A high level of lacZ expression was found in the granular layer of posterior lobe (lobules VII to X) in the postnatal NT-3(+/-) cerebellum. The expression in these regions was reduced with age. Although the Purkinje cells are considered to be a target of NT-3 and the NT-3(-/-) mice displayed severe moving disorders like ataxia, no histological abnormality was observed in their cerebellum. These findings suggest that the NT-3 expressed in the cerebellum gives some trophic effects primarily to the posterior lobe, however, the deficiency does not affect its development. |
