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Publication : The mouse 5-HT2B receptor: homologous subtype or species variant?

First Author  Choi DS Year  1996
Journal  Behav Brain Res Volume  73
Issue  1-2 Pages  253-7
PubMed ID  8788513 Mgi Jnum  J:31408
Mgi Id  MGI:78912 Doi  10.1016/0166-4328(96)00107-6
Citation  Choi DS, et al. (1996) The mouse 5-HT2B receptor: homologous subtype or species variant?. Behav Brain Res 73(1-2):253-7
abstractText  The recently characterized 5-HT2B subfamily of serotonin receptors has now been reported from three different species: human, rat and mouse. Their genomic structures include 2 introns present at identical positions. Despite this similarity, their respective protein sequences show some diversities. In addition, the pharmacology of these receptors is distantly related, and their sites of expression vary amongst species. Thus, it appears difficult at present to unambiguously classify these receptors into the same subfamily, raising the possibility of the existence of other 5-HT2B-like receptors, yet to be discovered.
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