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Publication : Isolation, characterization and chromosomal assignment of the human WNT7A gene.

First Author  Ikegawa S Year  1996
Journal  Cytogenet Cell Genet Volume  74
Issue  1-2 Pages  149-52
PubMed ID  8893824 Mgi Jnum  J:36081
Mgi Id  MGI:83532 Doi  10.1159/000134404
Citation  Ikegawa S, et al. (1996) Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenet Cell Genet 74(1-2):149-52
abstractText  The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization.
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