First Author | Ikegawa S | Year | 1996 |
Journal | Cytogenet Cell Genet | Volume | 74 |
Issue | 1-2 | Pages | 149-52 |
PubMed ID | 8893824 | Mgi Jnum | J:36081 |
Mgi Id | MGI:83532 | Doi | 10.1159/000134404 |
Citation | Ikegawa S, et al. (1996) Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenet Cell Genet 74(1-2):149-52 |
abstractText | The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization. |