| First Author | Wilkinson DG | Year | 1988 |
| Journal | EMBO J | Volume | 7 |
| Issue | 3 | Pages | 691-5 |
| PubMed ID | 3293998 | Mgi Jnum | J:9254 |
| Mgi Id | MGI:57717 | Doi | 10.1002/j.1460-2075.1988.tb02864.x |
| Citation | Wilkinson DG, et al. (1988) Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J 7(3):691-5 |
| abstractText | The proto-oncogene int-2 has been implicated in the formation of mouse mammary-tumour-virus-induced mammary tumours. Analysis of the predicted coding sequence indicates that int-2 is a member of the fibroblast growth factor family. Previous studies using Northern blot analysis suggested that normal expression of int-2 may be confined to extra-embryonic endoderm lineages of embryonic stages of mouse development. We have used in situ hybridization and Northern blot analysis to examine directly int-2 expression in embryo stem cells and in the developing embryo from early gastrulation to midsomite stages. Complex patterns of accumulation of int-2 RNA were observed in embryonic and extra-embryonic tissues. The data suggest multiple roles for int-2 in development which may include migration of early mesoderm cells and induction of the otocyst. |
