| First Author | Dorfman JR | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 4 | Pages | 329-35 |
| PubMed ID | 11017105 | Mgi Jnum | J:65116 |
| Mgi Id | MGI:1891793 | Doi | 10.1038/79783 |
| Citation | Dorfman JR, et al. (2000) CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat Immunol 1(4):329-35 |
| abstractText | T cell receptor (TCR) signaling triggered by recognition of self-major histocompatibility complex (MHC) ligands has been proposed to maintain the viability of naive T cells and to provoke their proliferation in T cell-deficient hosts. Consistent with this, the partially phosphorylated state of TCR zeta chains in naive CD4+ and CD8+ T cells in vivo was found to be actively maintained by TCR interactions with specific peptide-containing MHC molecules. TCR ligand-dependent phosphorylation of TCR zeta was lost within one day of cell transfer into MHC-deficient hosts, yet the survival of transferred CD4+ lymphocytes was the same in recipients with or without MHC class II expression for one month. Thus, despite clear evidence for TCR signaling in nonactivated naive T cells, these data argue against the concept that such signaling plays a predominant role in determining lymphocyte lifespan. |
