| First Author | Li XM | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 8 | Pages | 3216-9 |
| PubMed ID | 8871613 | Mgi Jnum | J:38374 |
| Mgi Id | MGI:85745 | Doi | 10.4049/jimmunol.157.8.3216 |
| Citation | Li XM, et al. (1996) Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol 157(8):3216-9 |
| abstractText | Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-gamma gene transfer results in a significant expression of IFN-gamma in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-gamma gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach. |
