| First Author | André M | Year | 2003 |
| Journal | FEBS Lett | Volume | 546 |
| Issue | 2-3 | Pages | 223-7 |
| PubMed ID | 12832044 | Mgi Jnum | J:84328 |
| Mgi Id | MGI:2667415 | Doi | 10.1016/s0014-5793(03)00576-3 |
| Citation | Andre M, et al. (2003) Heme oxygenase-1 induction by endogenous nitric oxide: influence of intracellular glutathione. FEBS Lett 546(2-3):223-7 |
| abstractText | To investigate the influence of glutathione (GSH) on cellular effects of nitric oxide (NO) formation, human colon adenocarcinoma cells were transfected with a vector allowing controlled expression of inducible nitric oxide synthase (iNOS). Protein levels of oxidative stress-sensitive heme oxygenase-1 (HO-1) were analyzed in the presence or absence of GSH depletion using L-buthionine-[S,R]-sulfoximine and iNOS induction. While no effect was observed in the presence of iNOS activity alone, a synergistic effect on HO-1 expression was observed in the presence of iNOS expression and GSH depletion. This effect was prevented by addition of N-methyl-L-arginine. Therefore, targeting of endogenous NO may be modulated by intracellular GSH. |
