| Type | MGI:General | Description | punctate intraneuronal amyloid beta staining is observed frequently in lower layers of the cerebral cortex in 2-month old animals mice at 5-6 months display amyloid plaques in the CA1 pyramidal cell layer of the hippocampus, with enhanced intraneuronal amyloid beta aggregates detectable at 4 months (increasing further until most animals have plaques at 6 months); accumulation of amyloid beta aggregates begins prior to plaque formation at 9 months of age, granular intraneuronal amyloid beta aggregates were frequent and widespread in (lower layers of ) the cerebral cortex, subiculum and CA1 hippocampal region; amyloid plaques are also observed in thalamic nuclei although APP expression is low cerebral amyloid deposition is seen in animals with high plaque load but this is not a prominent feature in mutants |
